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For both Zepbound and Retatrutide, there are concerns about: Pancreatitis (inflammation of the pancreas) Gallbladder problems Thyroid tumors (Zepbound includes a warning about medullary thyroid carcinoma based on animal studies) Low blood sugar, especially if combined with other diabetes medications People with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2 should not take these drugs

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ROS induces the activity of apoptosis-related enzymes, causing damage to the podocytes and promoting the proliferation of fibrotic cells to induce the synthesis of ECM (Tong et al., 2017)